Which symptom is NOT typically associated with the side effects of local anesthetics?

Fatigue is not a typical symptom associated with the side effects of local anesthetics. Local anesthetics primarily target nerve endings to block pain, and their most common side effects are related to the central nervous system or cardiovascular system. Symptoms like tinnitus, respiratory distress, and seizures can occur as a result of systemic toxicity from local anesthetics, particularly when these agents enter the bloodstream in significant amounts.

Tinnitus may present due to central nervous system stimulation or toxicity, where auditory changes can occur. Respiratory distress can arise from various factors, including potential airway obstruction or effects on the respiratory centers in the brain. Seizures are a well-documented serious complication of local anesthetic overdose, reflecting central nervous system excitation. In contrast, fatigue is more likely to be incidental or linked to other factors rather than a direct pharmacological effect of local anesthetics themselves.